Marburg Virus Essay

Published: 2021-07-07 00:09:14
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Category: Medical

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Genetic Code RNA and mRNA genomic determine the cDNA clones that originate from them which forms 3000 nucleotides out of a 3′ end Marburg Virus genome (MBG). Sequence shows are repetitive and have a full nucleoprotein (NP) gene during extreme 3′ end. At the final stage of 5′ end of NP mRNA is discovered and also polyadenylation for NP site. (3′ UUCUUCUUAUAAUU…) is the transcriptional start and (3′ UAAUUCUUUUU) is the end of MBG NP gene signal. TransmissionMarburg virus transmits from animals to humans. Being in contact with bat feces or aerosols without using gloves is the most original of the virus, for example, as two cases of tourists in Uganda back in 2008 (Amman and Towner. et al., 2015). When a person gets the infection from animals, he or she transmits to other people through contact with an infected person body fluid. Similar to other viral diseases like Ebola, if you get in touch with infected person blood or tissues by using their equipment or other objects you catch Marburg virus. Caregivers in homes or hospital can get infected by this virus through accidental contact with an infected patient needle. Burial practices by some communities where they come into contact with the body of an infected person, the virus will spread to the community. Transmission can occur through sex with a person who has been exposed to caves and mines inhabited by a flock of bats. The semen of an infected person transmit the virus to another individual. Target PopulationMarburg virus also is formerly known as Marburg hemorrhagic fever can infect anybody from children to adults. Mostly the people who love to adventure caves and forests are at high risk of infection. The bat that is affected gather in a cave together and a person might walk into the population spooking the bats and in the process get infected. The scientist who researches animals like monkeys is at high risk of the virus infection. For example, in Germany and Serbia, two outbreaks of the virus occurs in 1967 which is associated with green monkeys (Cercopithecus aethiops) transported from Uganda. (Hashiquachi and Saphire. et al., 2015) Is Marburg Virus Lytic or Lysogenic?egative strand known as RNA filovirus multiplies in cytoplasm cells after the process of endocytosis. RNA negative strand doesn’t combine with the genome cell host making the virus lytic and not lysogenic. This virus kills the host cell in an instant and doesn’t merge with the cell (Hashiquachi and Saphire. et al., 2015). Marburg virus starts with the flu then vomiting, diarrhea, rash and finally bleeding especially in the GI tract. Monkeys are the central origin of Marburg virus and patient who are infected are put in level 5 isolation chamber.Does Marburg virus have a vaccine?Marburg virus is a rear disease just like Ebola, and both have high fatality rates of 88%. When a person gets infected by Marburg virus, the illness starts immediately with a severe headache and malaise. The disease manifests between ranges of 5 to 7 days with a victim showing bleeding from several places. There is no specific antiviral treatment or vaccine available for the condition and people infected requires an efficient procedure which is supportive therapy. Patients infected with Marburg virus are severely dehydrated and in need of fluids or rehydration with a liquid mixed with electrolytes. This diseases first broke In Marburg Germany and its named after this place. (Amman and Towner. et al., 2015)Marburg viral infection is prevented through creating awareness to people especially In Uganda where it originates from bats and monkeys. People adventuring caves should wear protective gears when coming into contacts with bats. Scientists who are testing animals like monkeys in the lab should take precaution when taking fluid or tissues sample of the animals.ReferencesAmman, B. R., Jones, M. E., Sealy, T. K., Uebelhoer, L. S., Schuh, A. J., Bird, B. H., … & Towner, J. S. (2015). Oral shedding of Marburg virus in experimentally infected Egyptian fruit bats (Rousettus aegyptiacus). Journal of wildlife diseases, 51(1), 113-124. Hashiguchi, T., Fusco, M. L., Bornholdt, Z. A., Lee, J. E., Flyak, A. I., Matsuoka, R., … & Saphire, E. O. (2015). Structural basis for Marburg virus neutralization by a cross-reactive human antibody. Cell, 160(5), 904-912.

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